The contribution of different information sources to identify adverse effects of a medical device: a case study using a systematic review of spinal fusion

TitleThe contribution of different information sources to identify adverse effects of a medical device: a case study using a systematic review of spinal fusion
Publication TypeJournal Article
Year of Publication2014
AuthorsGolder S, Wright K, Rodgers M
JournalInternational Journal of Technology Assessment in Health Care
VolumeFirstView
Pagination1–7
Date Published11
ISSN1471-6348
URLhttp://journals.cambridge.org/article_S0266462314000506
DOI10.1017/S0266462314000506
Full Text

Abstract

Background: The most effective sources to search to identify adverse effects data for medical devices are currently unknown.

Methods: The included studies from a systematic review of the safety of recombinant human bone morphogenetic protein-2 (rhBMP-2) for spinal fusion were used for analysis. For each source searched, a record was made for each relevant publication of whether it was retrieved by the search strategy used and whether it was available in the database but not retrieved. To account for multiple publications of the same study, a record was made of the relevant studies identified. The sensitivity, precision, and number needed to read were calculated as well as the minimum combination of sources to identify all the publications or studies.

Results: There were eighty-two publications (forty-nine studies) included in the systematic review. Only one article was available in a database searched but not retrieved by our search strategy. Science Citation Index (SCI) and EMBASE both achieved the highest sensitivity (62 percent), followed closely by MEDLINE/PubMED (56 percent). With the search strategies used, the minimum combination of sources needed to identify all the publications was SCI, EMBASE, CENTRAL, and either MEDLINE or PubMED, in addition to reference checking, contacting authors and an automated current awareness service. In relation to identifying all the relevant studies, the minimum combination of studies was similar with the exclusion of CENTRAL.

Conclusions: To identify all the relevant publications or studies included in this case study systematic review, several different sources needed to be searched.

Keywords:

Adverse effects; Systematic review; Meta-analysis; Information storage and retrieval; Bibliographic databases

Footnotes

We thank Professor Lesley Stewart and Dr. Yoon Loke for their useful comments and suggestions.

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